The purpose of this study is to evaluate the effect of povorcitinib on the QT/QTc Interval in healthy participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
128
Povorcitinib will be administered at protocol defined dose.
Placebo will be administered at protocol defined dose.
Moxifloxacin will be administered at protocol defined dose.
Celerion Clinical Research Unit
Tempe, Arizona, United States
Change from Baseline in QT interval corrected using Fridericia's formula (QTcF)
Electrocardiogram measurement of the maximum absolute change from baseline in Fridericia's correction for QT interval (QTcF)
Time frame: Up to Day 3
Change from Baseline in heart rate (HR)
Electrocardiogram measurement of change from baseline in HR.
Time frame: Up to Day 3
Change from Baseline in the PR Interval (PR)
Electrocardiogram measurement of change from baseline in PR.
Time frame: Up to Day 3
Change from Baseline in the QRS interval (QRS)
Electrocardiogram measurement of change from baseline in QRS.
Time frame: Up to Day 3
Safety and tolerability as measured by the frequency, duration, and severity of adverse events (AEs)
An AE is defined as any untoward medical occurrence associated with the use of a drug in humans, whether or not considered drug related, that occurs after a subject provides informed consent.
Time frame: Up to Day 22
Povorcitinib concentration in plasma
Povorcitinib concentration in plasma.
Time frame: Up to Day 7
Moxifloxacin concentration in plasma
Moxifloxacin concentration in plasma.
Time frame: Up to Day 7
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