Effect of Letermovir Prophylaxis on CMV-specific Immune Reconstitution Post UCBT

Numbers of immune cells in peripheral blood

PBMCs from UCBT recipients were collected at 1 month, 2 month, 3 month, and 6 month and 12 month after HSCT, and tested for CMV-specific T cells, NK cells, T cells and other subsets.

Time frame: one year

CMV DNAemia

CMV DNAemia is defined as the detection of CMV DNA in samples of plasma, whole blood or isolated peripheral blood leukocyte.

Time frame: one year

Incidence of refractory CMV infection

Refractory CMV infection is defined as CMV viral load remaining at the same level or increasing despite appropriately doses of antiviral therapy for at least 2 weeks

Time frame: one year

late CMV reactivation

Late CMV reactivation is defined as reactivation that occurs 100 days post UCBT, which means reactivation after discontinuing LET prophylaxis.

Time frame: one year