Long-term Outcomes of Duodenal Adenocarcinoma From a Large Cohort

N/ANot Yet RecruitingNCT06443086

Nanfang Hospital, Southern Medical University400 enrolled

Overview

The investigators will conducted a hospital-based cohort study in our 15-year experience with DA aimed at investigating the long-term outcomes of the patients with DA, along with analyzing the impact of the tumor characteristics, operations and adjuvant therapy on survival outcomes.

Numerous meta-analyses and systematic reviews have delved into the treatment of DA, yet the majority of the studies retrospective, single-center, and small sample size series, particularly in China. To bridge this knowledge gap, the investigators will conduct a hospital-based cohort study designed to investigate the long-term survival outcomes of the participants with the non-ampulla duodenal adenocarcinoma, and the effects of tumor characteristics, surgery, and adjuvant therapy on survival outcomes.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Gastrointestinal Disease

Interventions

Radical operation and perioperative therapyPROCEDURE

Surgical intervention, particularly radical excision, was performed for each patient, including the extent of resection and lymph node dissection. Information on adjuvant therapies, such as chemotherapy and radiotherapy, was also recorded, specifying the regimens and durations.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion criteria: (1) histologically confirmed non-ampulla DA; Exclusion criteria: 1. had other gastrointestinal cancer; 2. had incomplete medical records, or lost follow-up shortly after diagnosis; 3. refused clinical data collection.

Outcomes

Primary Outcomes

Median overall survival time

Median survival is the time it takes half of the individuals in a given study population to reach or exceed a particular end event, calculated from the time an event occurred. Median survival is a statistical index describing the distribution of survival time.

Time frame: 2009.10-2023.06

3-year overall survival rate

Three-year survival rate, also known as survival rate, refers to the number of patients with a disease who are still alive at the end of three years of follow-up as a percentage of the number of cases observed

Time frame: 2009.10-2023.06

5-year overall survival rate

Five-year survival rate, also known as survival rate, refers to the number of patients with a disease who are still alive at the end of five years of follow-up as a percentage of the number of cases observed

Time frame: 2009.10-2023.06

Central Contacts

Hao Liu, MD, PhD

CONTACT

+86-20-62787626 hao.liu@alumni.uni-heidelberg.de

Data from ClinicalTrials.gov

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