Transient Receptor Potential Channels

Early Phase 1RecruitingNCT06444594

Penn State University45 enrolled

Overview

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Aging

Interventions

TRPM8 AgonistDRUG

menthol gel 4-10%

TRPV1 AgonistDRUG

camphor gel 5-20%

TRPV4 AgonistDRUG

capsaicin gel 0.05-1%%

TRPM8, TRPV4, TRPV1 Agonists

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-85 years old. * Women will not be pregnant and/or breastfeeding. Exclusion Criteria: * Currently pregnant or breastfeeding * Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime) * Known skin allergies or current rash, skin disease, disorders of pigmentation * Diabetes * Body mass index \>35kg\*m-2 * Using calcium channel blockers * Raynaud's syndrome * Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive * Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Locations (1)

Noll Laboratory

University Park, Pennsylvania, United States

RECRUITING

Outcomes

Primary Outcomes

Skin blood flow during slow local heating

Laser doppler flowmeter to measure skin blood flow during a slow local heating of the skin

Time frame: 75 minutes

Somatosensory perception

heat and cold perception using a visual analog scale

Time frame: every 5 minutes for 120 minues

algometer measurement

pain pressure thresholds

Time frame: every 30 minutes for 120 minutes

Central Contacts

Lacy Alexander, Ph.D.

CONTACT

8148671781 lma191@psu.edu

Sue K Slimak, R.N.

CONTACT

Data from ClinicalTrials.gov

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