Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Connecticut Children's Medical Center52 enrolled

Overview

Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management. POCUS can be used to diagnose the severity of neonatal respiratory distress syndrome (RDS) through a lung ultrasound score. Lung ultrasound scores have also been shown to predict if an infant is treated with an initial dose of surfactant. Therefore, using lung ultrasound scores to guide surfactant therapy for RDS will likely lead to earlier surfactant therapy and may improve short-term respiratory outcomes. This study will test this theory by comparing lung ultrasound score-guided surfactant therapy for premature infants with RDS with our current surfactant administration guidelines.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Distress Syndrome, Newborn Pulmonary Surfactants Intensive Care Units, Neonatal

Eligibility

Sex: ALLMin age: 0 HoursMax age: 2 Hours

Medical Language ↔ Plain English

Inclusion Criteria: * The infant's parent/legal guardian can understand and willingly sign a written informed consent document for this study * Birth gestational age between 27w0d-36w6d * Diagnosis of respiratory failure secondary to RDS requiring respiratory support with non-invasive positive pressure ventilation Exclusion Criteria: * Unable to obtain lung ultrasound between 1-2 hours of life * Infants already intubated or received surfactant before the point of care lung ultrasound * Infants born with congenital cardiac disease, congenital lung disease, or congenital facial/airway malformations * Infants born with chromosomal abnormalities * Infants with APGARs ≤ 5 at 10 minutes of life * Infants requiring cardiopulmonary resuscitation or therapeutic hypothermia in the first 6 hours of life

Outcomes

Primary Outcomes

Oxygen Saturation Index

(CPAP Level x FiO2)/(SpO2)

Time frame: At 24 hours of life.

Secondary Outcomes

Oxygen Saturation Index

(CPAP Level x FiO2)/(SpO2)

Time frame: At 48 and 72 hours of life.