The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
The focus of this study is Aim 1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
150
Participants will complete one session of mindfulness-based fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.
Participants will complete one session of control fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.
Connecticut Mental Health Center
New Haven, Connecticut, United States
RECRUITINGChange in within-Default Mode Network (DMN) resting state functional connectivity after one session of neurofeedback (NF)
Defined as within-DMN connectivity as the resting state seed-based connectivity between core nodes of medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Change = post-NF within-DMN connectivity - pre-NF within-DMN connectivity.
Time frame: From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day
Change in DMN-Frontoparietal Control Network (FPCN) anticorrelation in resting state functional connectivity data after one session of neurofeedback
Defined as DMN-FPCN anticorrelation as the fMRI seed-based connectivity from mPFC to dorsolateral prefrontal cortex (dlPFC)). Change = post-NF mPFC-dlPFC anticorrelation - pre-NF mPFC-dlPFC anticorrelation
Time frame: From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day
Change from baseline in state mindfulness on State Mindfulness Scale (SMS) score on same day after neurofeedback.
The State Mindfulness Scale (SMS) is a validated self-reported 21 item instrument assessing state mindfulness over the past 15 minutes. Possible scores range from 21 (not mindful) to 105 (very mindful).
Time frame: From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day
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