Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain. The aim of the study is to evaluate inflammation and endothelial dysfunction biomarkers in MINOCA patients during both acute and stable phases, comparing them with those with MI and obstructive coronary arteries (MICAD).
Prospective observational study in patients with Myocardial Infarction (MI) divided into two groups: MI with obstructive coronary arteries (MICAD) and MI with non-obstructive coronary arteries (MINOCA). Levels of interleukin-6, tumor necrosis factor-alpha, high-sensitivity C- reactive protein, and asymmetric dimethylarginine will be determined at three time points: within the 24 hours from the onset of pain, discharge, and two months after MI. The association of biomarkers, normalized by peak troponin value, with the risk of MINOCA will be evaluated using logistic regression.
Study Type
OBSERVATIONAL
Enrollment
400
Patients were classified as MICAD or MINOCA by the presence or absence of an epicardial vessel with ≥50% stenosis after performing a coronariography.
Hospital Universitario de Getafe
Getafe, Madrid, Spain
RECRUITINGLevels of interleukin-6 (pg/ml) and tumor necrosis factor-alpha (pg/ml)
Levels of interleukin-6 (pg/ml) and tumor necrosis factor-alpha (pg/ml) will be determined.
Time frame: At three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
Levels of endhotelial disfunction biomarkers
Levels of asymmetric dimethylarginine will be determined
Time frame: At three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
Levels of high-sensitivity C-reactive protein (mg/L)
Levels of high-sensitivity C-reactive protein (mg/L) will be determined.
Time frame: t three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
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