The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.
Study Type
OBSERVATIONAL
Enrollment
600
Hospital Anxiety and Depression Scale questionnaire is used to test patients for anxiety and depression.
Tongji hospital
Wuhan, Hubei, China
RECRUITINGHADS score
Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression.
Time frame: during hospital stay, average of 1 week
Interleukin (IL）-1β plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-1β （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-2 receptor plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-2 （u/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-6 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-6 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-8 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-8 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-10 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-10 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
Interferon(INF)-α plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines INF-α （pg/ml）will be tested.
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Time frame: during hospital stay, average of 1 week
Brain-derived neurotrophic factor (BDNF) plasma level
Blood sample will be obtained from enrolled patients and the plasma level of BDNF（pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
C-reactive protein (CRP) plasma level
Blood sample will be obtained from enrolled patients and the plasma level of CRP（mg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging
Functional brain magnetic resonance imaging will be performed in patients with anxiety or depression, and area under curve (AUC) of topological metrics including Eglob,Eloc,Cp,Lp,γ,λ and σ will be calculated and analyzed.
Time frame: during hospital stay, average of 1 week