Endocrine Determinants of Renal Function in Patients With Hypoparathyroidism

IRCCS San Raffaele46 enrolled

Overview

Endocrine determinants of renal function in patients with hypoparathyroidism on conventional treatment: a cross-sectional study (ENDORSE)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypoparathyroidism

Interventions

Blood sample and urine collectionDIAGNOSTIC_TEST

Blood sample and urine collection as per clinical practice

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 18 years * diagnosis of chronic (≥ 1 year) post-surgical and autoimmune hypoparathyroidism, as established with undetectable or insufficient PTH concentration in relation to the presence of hypocalcemia * patients being treated with calcitriol or alfacalcidiol * patients able to sign the written informed consent Exclusion Criteria: * pregnancy * severe renal failure requiring dialysis treatment * macroproteinuria * use of antihypertensive drugs such as thiazides, ACE inhibitors, sartans, beta and alpha blockers, and antialdosterone drugs * pazients affected by diabetes mellitus- insulin-treated

Locations (1)

Andrea Giustina

Milan, Italy

Outcomes

Primary Outcomes

The rate of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism

Evaluation of the prevalence of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism (hypoPTH) in conventional treatment with calcium and vitamin D

Time frame: 12 months

Data from ClinicalTrials.gov

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