The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses. The main questions it aims to answer are: * do low-dose atropine and soft multifocal contact lenses affect the shape of the peripheral eye? * are changes in peripheral eye shape from these interventions influenced by changes in the focusing system of the eye? Participants will: * have multiple different types of photos taken * have their prescription for glasses/contacts checked * have their eye health checked, including the use of dilating eye drops * be randomly assigned to use eye drops every night or wear special contact lenses daily instead of their typical contacts * will complete five study visits over the course of 12 months Researchers will compare young adults using low-dose atropine to those wearing soft multifocal contact lenses and to those using no intervention to see if using these interventions affects retinal shape.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
75
0.05% atropine ophthalmic solution
soft multifocal contact lenses
The Ohio State University
Columbus, Ohio, United States
Change in ocular shape
ocular shape, as measured by the ellipsoid fit of the retina acquired by the photos taken with ocular ultrasound (ABSolu, Quantel Medical)
Time frame: baseline to 12 months
Axial elongation (or regression)
change in axial length of the eye, as measured by Lenstar 900 (Haag-Streit)
Time frame: baseline to 12 months
Change in accommodative response
change in focusing ability of the eye, as measured with near targets and the Grand Seiko WR-5100K
Time frame: baseline to 12 months
Change in refractive error
change in refractive error, as measured with the Grand Seiko WR-5100K
Time frame: baseline to 12 months
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