FET-PET/MRI Based Treatment Planning for Glioblastoma Multiforme in Post-Surgical Patients (FET-TREAT)

Sunnybrook Health Sciences Centre11 enrolled

Overview

Glioblastoma multiforme (GBM) represent the most common primary brain malignancy and prognosis remains poor. The most common subtype is glioblastoma which has a 5-year survival rate of approximately 5%. Despite advances in MRI techniques, accurately determining total extent of tumor remains a challenge. The result is incomplete treatment resulting in reduced survival or overtreatment resulting in avoidable treatment related morbidity. A more accurate means of assessing tumor extent is needed to guide management to improve patient survival and quality of life.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glioblastoma Multiforme

Interventions

FET-PET/MRIDIAGNOSTIC_TEST

Radiation planning target volume (PTV) when planned with FET-PET/MRI to PTV when planned with conventional (Standard of Care) MRI only. 0-(2-18F-Fluoroethyl)-L-Tyrosine (FET) 180-200 megabecquerel (MBq) administered intravenously prior to PET/MRI imaging.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: Each participant must meet all of the following inclusion criteria to participate in this study: * ≥ 18 years of age * Diagnosis of glioblastoma multiforme * Post-maximally safe surgical resection * No prior radiation or systemic treatment for high grade glioma * Able to tolerate PET/MRI scan with intravenous contrast * Willing to provide informed consent Exclusion Criteria: All participants meeting any of the following exclusion criteria at baseline screening will be excluded from participation in this study: * MRI contraindication * Creatinine clearance \< 30mL/min * Inability to lie still for 60 minutes * Gadolinium allergy * Positive pregnancy test * Breastfeeding * Patient unable to follow the protocol for any reason

Outcomes

Primary Outcomes

Difference in radiation treatment volume as determined by FET-PET/MRI compared to standard of care MRI.

Volume difference measured in cubic centimetres

Time frame: 12 months