Pecs Block vs Local Infiltration in Mastectomy

Hasanuddin University30 enrolled

Overview

Studied the comparison between PECS II block and LIA on pain intensity, opioid requirements, RNL, and postoperative IL-6 levels in MRM patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Pain, Postoperative

Interventions

PECS II blockDRUG

Treatment group that received the PECS II block using isobaric bupivacaine 0.5% 50 mg

LIADRUG

Treatment group that received the local infiltration anesthesia using isobaric bupivacaine 0.5% 50 mg

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 18-60 years old. 2. Body weight (BW): 50-70 kg. 3. Height (TB): 150-170 cm. 4. Body mass index (BMI): 18.5-29.9 kg/m2. 5. American Society of Anesthesiologists physical status (ASA PS) class I-II. 6. Patients undergoing elective MRM surgery under general anesthesia. Exclusion Criteria: 1. Patients with contraindications to PECS II block. 2. Patients with contraindications to LIA. 3. Patients with coagulation disorders or receiving anticoagulant therapy. 4. Patients with a history of chronic pain. 5. Patients with a history of allergy to study materials. 6. Patients with a history of previous breast surgery. 7. Patient refuses to participate in the study.

Locations (1)

RSUP dr. Wahidin Sudirohusodo

Makassar, South Sulawesi, Indonesia

Outcomes

Primary Outcomes

Concentration of Plasma Interleukin-6

in pg/dL

Time frame: 1 hour before surgery, 2 hour after surgery, 12 hour after surgery

Neutrophil-lymphocyte ratio

Neutrophil divided by lymphocyte

Time frame: 1 hour before surgery, 2 hour after surgery, 12 hour after surgery

Pain intensity (Using Numeric Rating Scale)

Scale from 0-10, lower score = better outcome

Time frame: hour 0, 2, 4, 6, 12, 24

Rescue opioid requirement

Using fentanyl at a dose of 0.5-1 μg/kg/IV titrated as needed, in mcg (given if the patient had NRS of \>4/10)

Time frame: Within 24 hours after surgery

Secondary Outcomes

Demographic baseline data

Medical record number, age, body weight (in kilogram), height (in centimeter), BMI (in kg/m2), ASA PS class, duration of surgery (in minutes)

Time frame: baseline (before the surgery)

Time until first rescue opioid requirement

in minutes

Time frame: Within 24 hours after surgery

Nausea and vomiting

Nausea and vomiting were assessed using a numerical scale (0 = no nausea, 1 = mild nausea, 2 = severe nausea or vomiting once, and 3 = vomiting more than once). If the score was \> 2, rescue antiemetics with ondansetron 0.1 mg/IV were given.

Time frame: Within 24 hours after surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.