Prediction of the Response to a Course of Transcranial Magnetic Stimulation (rTMS) Based on Heart Rate Variability

Inclusion Criteria: * Having a prescription for a course of rTMS to treat an episod of MDD * Unipolar MDD confirmed according to DSM-5 criteria * Moderate to severe MDD (MADRS score \> 19) * No use of psychotropic medication or use stabilised (no change in dose \< 4 weeks before study entry) * Able to understand, speak, read and write French * Express informed consent, after a period of reflection * Affiliated with a French social security scheme or beneficiary of such a scheme Exclusion criteria: * History of epilepsy or convulsive seizures * Previous brain surgery * History of recent cranial trauma (\< 6 months) * Presence of severe suicidal ideation * Psychotic disorders * Metal objects in the head, eyes or brain * Implanted ferromagnetic equipment (pace maker, cochlear implant, etc.) * Clinical evidence of serious or uncontrolled alcohol or substance use disorders in the three months prior to the study * Active withdrawal from alcohol or other substances * One or more recent rTMS sessions (\< 4 weeks) * Other non-drug therapy recently initiated (\< 4 weeks) to treat MDD (psychotherapy, phototherapy, vagus nerve stimulation, etc.) * Prescription of cardiotropic drugs belonging to the following classes: predominantly cardiac calcium channel blockers, Vaughan Williams class I anti-arrhythmics and beta-blockers. * Subjects in a period of relative exclusion from another protocol * Adults protected by law or patients under guardianship or curatorship * Subjects deprived of their liberty by judicial or administrative decision * Pregnant or breast-feeding women