This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).
This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
54
Participants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity.
Participants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation.
For non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States
RECRUITINGEnrollment/Baseline
Enrollment will be defined as the number of participants who were recruited and consented to the study.
Time frame: Enrollment
Retention
Retention will be defined as the number of participants who completed the 12-week exercise treatment.
Time frame: Baseline to end of 12-week treatment
Compliance
Compliance will be defined by the proportion of completed treatment sessions.
Time frame: Baseline to end of 12-week treatment
Acceptability
Acceptability will be recorded by conducting interviews with participants who completed the 12-week exercise treatment.
Time frame: End of 12-week treatment
Gait Speed
Change in gait speed will be assessed after 12-week exercise treatment.
Time frame: Baseline to end of 12-week treatment
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