Glymphatic MRI Study

Inclusion Criteria: * Ability to undergo MRI without anesthesia * Calculated GFR greater or equal to 60 mL/min/1.73 m2 Exclusion Criteria: * Inability to obtain consent * Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant * Known allergic or hypersensitivity reactions to gadolinium * Three or more drug allergies from separate drug classes * Recent or expected beed for imaging with iodinated contrast * Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe * History of neurosurgical procedure or cervical surgery * Current use of anticoagulation medications * Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)