In an effort to prevent or treat consistently high rates of PONV following maxillofacial operations, several medications, techniques and multimodal protocols have been studied. In the present study, the investigators hypothesized that combining metoclopramide with granisetron will improve PONV incidence when compared with granisetrone alone.
Despite advances in anesthetic techniques and antiemetic drugs that accompany increasing awareness of anesthesia providers, postoperative nausea and vomiting (PONV) remains one of the most common problems after general anesthesia. PONV is one of the major problems leading to patient dissatisfaction, prolonged stay in postoperative care unit and hospital, readmissions and thus it can increase health care costs. In the studies performed in PONV prone patients and high-risk surgeries, as compared with other antiemetic medications, "setrons" provided lower nausea and vomiting incidence postoperatively, but were unable to completely prevent this "big little" problem.The blood in the stomach has been indicated as one of the major causes of PONV following maxillofacial surgery thus, using metoclopramide may relieve the complaints by evacuating this irritant. After institutional ethic committee and National Medicines, 66 consecutive patients, classified as ASA I and II physical status and aged between 18 and 60 years were included in the study. Apfel's simplified PONV risk score including female sex, history of motion sickness or PONV, smoking status and predicted use of postoperative opioids was recorded.Procedures were performed under general anesthesia. Patients in Group G received 3 mg granisetron (Neoset, Deva, Istanbul) and the patients in group GM received 3 mg granisetron + 10 mg metoclopramide (Metpamid, Sifar İlaç, Istanbul) 30 minutes before the end of operation intravenously. A nursing staff collected the data concerning PONV, VAS, systolic, diastolic and mean arterial pressures, heart rate, peripheral arterial saturation, total doses of drugs used, overall bleeding score, infused fluid volume, VAS, surgical procedure, duration of surgery and rescue antiemetics for nausea if applied for 24 hours.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
66
medications were applied intravenously to the groups 30 minutes before end of the procedure
Bezmialem Vakif University
Istanbul, Fatih, Turkey (Türkiye)
Postoperative nausea and vomiting
The primary outcome of interest in the present study was the incidence of PONV.
Time frame: fully awake and on the 1st, 2nd, 4th, 6th , 8th and 24th hours postoperatively
Visual analogue scale
Visual analogue scale was used to record pain score. following the surgery. 0-10 point scale was used. 0 showed no pain, 10 showed worst pain status.
Time frame: fully awake and on the 1st, 2nd, 4th, 6th , 8th and 24th hours postoperatively
Systolic arterial pressure
It was measured during the surgery.
Time frame: preoperatively, at the induction, every 30 minutes interval till the end of the surgery, before extubation.
Diastolic arterial pressure
It was measured during the surgery.
Time frame: preoperatively, at the induction, every 30 minutes interval till the end of the surgery, before extubation.
Mean arterial pressure
It was measured during the surgery.
Time frame: preoperatively, at the induction, every 30 minutes interval till the end of the surgery, before extubation.
heart rate
It was measured during the surgery.
Time frame: preoperatively, at the induction, every 30 minutes interval till the end of the surgery, before extubation.
peripheral arterial saturation
It was measured during the surgery.
Time frame: preoperatively, at the induction, every 30 minutes interval till the end of the surgery, before extubation.
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total doses of drugs
It was recorded during the surgery.
Time frame: before extubation
Bleeding amount
It was recorded at the end of the surgery.
Time frame: before extubation
Infused fluid volume
It was recorded during the surgery.
Time frame: before extubation
Duration of surgery
It was recorded at the end of the surgery.
Time frame: before extubation
Rescue antiemetic
It was recorded at the end of the follow-up period.
Time frame: it was recorded until follow-up period ended and if applied it would be recorded. Between fully awake in ward and 24th hours postoperatively.