Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography

Sohag University200 enrolled

Overview

the aim of this study is to assess the impact of duration of DM on OCTA parameters in diabetic patients without clinical Diabetic retinopathy.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Diabetic Retinopathy, DR

Interventions

optical coherence tomography angiographyDIAGNOSTIC_TEST

A non-invasive eye imaging technique that creates high-resolution, 3D maps of blood flow in the retina and choroid by comparing sequential OCT scans to detect the motion of red blood cells to provide a visual contrast to the static tissue that allows the visualization the retinal microvasculature without needing an injectable dye, unlike traditional angiography.

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Type of DM: Type 2. 2. Fundus examination: no macular edema or other signs of clinical retinopathy Exclusion Criteria: 1. Ocular history : any history of significant ocular injury or disease that could affect the retinal microvasculature such as retinal vascular occlusion, glaucoma, or vitreo-macular disease, as such conditions have also been noted to show sub-clinical OCTA changes \[13, 14\]. 2. Fundus examination: macular edema or any other signs of clinical retinopathy

Locations (1)

Sohag university hospital

Sohag, Sohag Governorate, Egypt

Outcomes

Primary Outcomes

FAZ metrics

FAZ area, FAZ perimeter \& FAZ flow density

Time frame: baseline

Superficial Vessel Density

foveal, average parafoveal \& average perifoveal

Time frame: baseline

Deep Vessel Density

foveal, average parafoveal, average perifoveal

Time frame: baseline

SCP thickness

foveal, average parafoveal \& average perifoveal

Time frame: baseline

DCP thickness

foveal, average parafoveal \& average perifoveal

Time frame: baseline

Sectoral superficial vessel density

superior parafoveal, inferior parafoveal, nasal parafoveal, temporal parafoveal, superior perifoveal, inferior perifoveal, nasal perifoveal \& temporal perifoveal

Time frame: baseline

Sectoral deep vessel density

superior parafoveal, inferior parafoveal, nasal parafoveal, temporal parafoveal, superior perifoveal, inferior perifoveal, nasal perifoveal \& temporal perifoveal

Time frame: baseline

Data from ClinicalTrials.gov

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