Sequential Combination Therapy With PD-1 Antibody and Peg-IFNα in CHB Patients

Inclusion Criteria: * 1\. 18 - 65 years old; * 2.Chronic hepatitis B patients with clear diagnosis of hematology, etiology and clinical (for example: HBsAg positive for more than 6 months); * 3\. In virologically suppressed (HBV DNA below the lower detection limit) CHB patients by NAs treatment, HBsAg decreased by less than 0.5log in the last 6 months of Peg-IFNα therapy, and then discontinued Peg-IFNα at least 6 months; * 4.Patients with HBV DNA negative, HBeAg negative, HBsAg quantification ≤ 200IU/ml at Peg-IFNα discontinuation and enrollment. Exclusion Criteria: * 1\. Cirrhosis; * 2.platelet count \< 90×109/L, WBC count \< 3.0×109/L, neutrophil count \< 1.3×109/L, ALT \> ULN (40U/L), total bilirubin \> 2ULN; * 3.History of or suspicion of hepatocellular carcinoma * 4.Patients received immunosuppressive therapy or other therapy influenced study within 12 months; * 5.Hepatitis A, hepatitis C, hepatitis D, HIV infection or other active infections; * 6.Alcohol or drug abuse/dependence; * 7.Investigator judges that the participants are not suitable for this study.