The primary objective of this study is to evaluate the efficacy of train-of-four (TOF) monitoring using the TetraGraph Neuromuscular Transmission Monitor in pediatric patients less than 1 year of age.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
50
TetraGraph is a unique, EMG-based portable device for quantitative (objective) monitoring of neuromuscular function. It is a precise and easy to use tool for monitoring depth of block, ensuring adequate recovery of muscle function, and aiding the clinician to reduce the incidence of residual block.
Nationwide Children's Hospital
Columbus, Ohio, United States
TOFr (%)
The Train of Four ratio (TOFr) is a quantitative measure used in anesthesia to assess the depth of neuromuscular blockade and recovery, calculated by dividing the amplitude of the fourth twitch by the first twitch after four 2-Hz stimuli. A TOF ratio is the standard threshold for safe extubation and indicates sufficient recovery from nondepolarizing agents. A TOF ratio \>/= 90% is the standard threshold for safe extubation and indicates sufficient recovery from nondepolarizing agents.
Time frame: During the surgery (1-3 hrs. avg.)
Amplitude
The amplitude of the muscle action potential in response to electrical stimulation of its corresponding peripheral nerve.
Time frame: During the surgery (1-3 hrs. avg.)
Rate of Muscle Recovery
The amount of time from administration of neuromuscular blockade reversal agent to muscle recovery (TOFr \>/= 90).
Time frame: Baseline, After reversal of neuromuscular blockade during surgery (avg of 1-3 hrs)
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