Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

University of Pittsburgh100 enrolled

Overview

The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field (7 Tesla) functional magnetic resonance imaging. The overall approach is a condition-intensive within-subjects design, with extensive sampling of individual participants, including a group who have had strokes impacting the cerebellum, across multiple sessions. Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requirement for participation. The experimental sessions involve behavior and non-invasive brain imaging. Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception (e.g., reading passages or words aloud, making judgements about sounds). In one session, Investigators will measure electroencephalography (EEG) while participants complete tasks involving producing and hearing speech sounds. Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes. In other sessions, investigators will measure structural and functional magnetic resonance imaging (fMRI). Structural images demonstrate the unique brain anatomy of the participant. Functional images will be obtained while the participant completes specific tasks involving listening, speaking, or completing other motor actions (e.g., pressing a button). All participants will be screened for MRI risk factors prior to each session.

Study Type

INTERVENTIONAL

Allocation

Interventions

Neural responses to speech functional localizerBEHAVIORAL

Measuring speech-related brain activity using fMRI during a speech listening task.

Neural responses to silent articulationBEHAVIORAL

Measuring speech-related brain activity using fMRI during a silent articulation task.

Neural responses to self vs. externally generated speechBEHAVIORAL

Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.

Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech

Neural responses to induced speech errorsBEHAVIORAL

Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.

Neural responses to sensory-motor adaptationBEHAVIORAL

Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.

Speech production behaviorsBEHAVIORAL

Behavioral measurements of speech during reading passages and words

Auditory acuity testingBEHAVIORAL

Measurements of auditory acuity during listening tasks.

Neural responses to learning a non-speech auditory motor behaviorBEHAVIORAL

Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Cohort 1 (neurotypical adults): * Age 18-49 * Right-handed * Native English speaker Cohort 2 (people with cerebellar lesions): * Age 18 or older * Right-handed * Native English speaker * History of cerebellar stroke Cohort 3 (controls matched to Cohort 2) * Age 18 or older * Right-handed * Native English speaker Exclusion Criteria: Cohort 1 (neurotypical adults): * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant * History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury) * Hearing loss, defined by pure tone thresholds \>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium) * Presence of a severe and unmanaged, clinically diagnosed attention disorder * Clinically diagnosed with or treated for a speech, language, or hearing disorder * Head circumference greater than 60cm or weight greater than 300 pounds * History of severe claustrophobia * Currently pregnant Cohort 2 (people with cerebellar lesions): * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant * History of neurological / neurodegenerative disease or severe brain injury other than stroke * Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium) * Presence of a severe and unmanaged, clinically diagnosed attention disorder * Head circumference greater than 60cm or weight greater than 300 pounds * History of severe claustrophobia * Currently pregnant Cohort 3 (controls matched to Cohort 2): * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant * History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury) * Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium) * Presence of a severe and unmanaged, clinically diagnosed attention disorder * Clinically diagnosed with or treated for a speech, language, or hearing disorder * Head circumference greater than 60cm or weight greater than 300 pounds * History of severe claustrophobia * Currently pregnant

Outcomes

Primary Outcomes

Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech

The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.