This study medicine NNC0487-0111 to improve the treatment options for people living with overweight and obesity or with type 2 diabetes. The purpose of the study is to investigate if NNC0487-0111 affects how effective birth control pills are. Participants will take 1-tablet once daily. The study medicine will taken orally for 18 weeks and then study medicine will be injected with a thin needle in a skin fold in the abdomen for 9 weeks.The study will last for about 35 weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
43
NNC0487-0111 A will be administered subcutaneously.
NNC0487-0111 C will be taken orally.
Levonorgestrel 150 μg + Ethinylestradiol 30 μg (Oral contraceptive OC) will be taken orally.
Acetaminophen - 500 mg/15 ml will be taken orally.
Altasciences Clinical Company, Inc
Montreal, Quebec, Canada
The area under the ethinylestradiol plasma concentration time curve at steady state
Measured as hours picograms per milliliter (h\*pg/mL).
Time frame: Day 8 and Day 193
The area under the levonorgestrel plasma concentration time curve at steady state
Measured as hours picograms per milliliter (h\*pg/mL).
Time frame: Day 8 and Day 193
Maximum ethinylestradiol plasma concentration at steady state
Measured as picograms per milliliter (pg/mL).
Time frame: Day 8 and Day 193
Maximum levonorgestrel plasma concentration at steady state
Measured as picograms per milliliter (pg/mL).
Time frame: Day 8 and Day 193
The area under the ethinylestradiol plasma concentration time curve at steady state
Measured as hours picograms per milliliter (h\*pg/mL).
Time frame: Day 8 and Day 135
The area under the levonorgestrel plasma concentration time curve at steady state
Measured as hours picograms per milliliter (h\*pg/mL).
Time frame: Day 8 and Day 135
Cmax,EE,SS, maximum ethinylestradiol plasma concentration at steady state
Measured as picograms per milliliter (pg/mL).
Time frame: Day 8 and Day 135
Cmax,LN,SS, maximum levonorgestrel plasma concentration at steady state
Measured as picograms per milliliter (pg/mL).
Time frame: Day 8 and Day 135
AUC1 area under the acetaminophen concentration-time curve following a standardised meal
Measured as hours micro grams per milliliter (h\*μg/mL).
Time frame: Day 1 and Day 186
AUC2 area under the acetaminophen concentration-time curve following a standardised meal
Measured as hours micro grams per milliliter (h\*μg/mL).
Time frame: Day 1 and Day 186
Cmax,para, maximum acetaminophen plasma concentration following a standardised meal
Measured as micrograms per milliliter (μg/mL).
Time frame: Day 1 and Day 186
AUC3 area under the acetaminophen concentration-time curve following a standardised meal
Measured as hours micro grams per milliliter (h\*μg/mL).
Time frame: Day 1 and Day 128
AUC4 area under the acetaminophen concentration-time curve following a standardised meal
Measured as hours micro grams per milliliter (h\*μg/mL).
Time frame: Day 1 and Day 128
Cmax,para, maximum acetaminophen plasma concentration following a standardised meal
Measured as micrograms per milliliter (μg/mL).
Time frame: Day 1 and Day 128
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