Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)

N/ANot Yet RecruitingNCT06464666

Yonsei University250 enrolled

Overview

AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits. RRI(Renal Resistive Index) is a non-invasive test measured by ultrasound and could be a useful tool to evaulate renal insult in the early phase. Early detection of renal insult and prevention of progression to AKI can contribute to reduing mortality and morbidity in cardiac surgical patients.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Acute Kidney Injury Renal Resistive Index

Interventions

Renal interlobar artery USPROCEDURE

By using convex US transducer, first find interlobar artery. Then get a pulsed wave doppler at renal interlobar artery for similar 3 to 5 waveforms. Measure peak systolic and minimum diastolic velocity and calculate RRI value.

Renal inter-lobular artery USPROCEDURE

Eligibility

Sex: ALLMin age: 19 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 19 years and older scheduled for cardiac surgery using CPB Exclusion Criteria: * Emergency opeartion, pre-operative shock status requiring vasopressor or inotropics, s/p kidney transplant patients, CKD stage 4 and 5 patients, patients who have renal artery stenosis or history of renal artery stent implantation, patients who have ascites with Child-Pugh classification B or C, In case of CPB weaning failure, In case of poor lung function and PaO2 or PaCO2 cannot be maintained within normal range.

Outcomes

Primary Outcomes

post-operative AKI incidence

The definition of AKI refers to Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury.

Time frame: within first 1 week after surgery

Secondary Outcomes

Major adverse kidney outcome (MAKE) 30

MAKE30 includes new dialysis, eGFR decrease more than 25% from the baseline, and mortality

Time frame: within first 1 month after surgery