Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.
Study Type
OBSERVATIONAL
Enrollment
100
Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.
University Hospital,
Lille, France
RECRUITINGSubtest of divided attention of the Test of Attentional Performance (TAP)
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
N200 amplitude and latency
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
Strength of EEG functionnal connectivity during an attentional task (global and regional)
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
Variation of power in several frequency bands (theta, alpha and beta) during an attentional task.
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
Magnetic resonance imaging functional connectivity.
Time frame: up to 5 days
Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus.
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
P300 amplitude and latency
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame: 24 hours
Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus.
Time frame: 24 hours
Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus.
Time frame: 24 hours
Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus.
Time frame: 24 hours
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