A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults

Inclusion Criteria: * Healthy participants with suitable veins for cannulation or repeated venipuncture at the time of consent. * All women must have a negative serum pregnancy test at the Screening Visit. * Women of childbearing potential must have a negative urine pregnancy test on admission to the Clinical Unit. * Women of childbearing potential must not be lactating and if heterosexually active must agree to use an approved method of highly effective contraception, to avoid pregnancy from 3 months prior to administration of the study drug and until 360 days after the dose of the study drug. * Women of non-childbearing potential must be confirmed at the Screening Visit by fulfilling one of the following criteria: 1. Postmenopausal defined as amenorrhea for at least 12 months following cessation of all exogenous hormonal treatments and follicular stimulating hormone (FSH) levels in the postmenopausal range. 2. Documentation of irreversible surgical sterilization by complete hysterectomy, bilateral oophorectomy, or bilateral salpingectomy but not tubal ligation or tubal occlusion. * Have a Body mass index ≥ 18.0 to ≤ 32.0 kg/m2 and weigh ≥ 45 kg and ≤ 110 kg. * Willing and able to complete the Follow-up Period through Day 361. * Healthy Chinese participants - participants of Chinese descent are eligible based on meeting all of the following specific criteria for these two cohorts (Cohorts 2b and 4b): 1. Participant with Chinese ancestry, born in mainland China, Hong Kong, or Taiwan. 2. Participant is the descendant of 4 ethnic Chinese grandparents and 2 ethnic Chinese parents. 3. Participant has lived outside China for ≤ 10 years at the time of Screening. 4. Exhibits no significant change in lifestyle, including diet, since leaving China. Exclusion Criteria: * History of any clinically important disease or disorder which may either put the participant at risk because of participation in the study or influence the results or the participant's ability to participate in the study. * Any clinically important illness, medical/surgical procedure, or trauma within 4 weeks of the first administration of study drug. * History of malignancy other than treated non-melanoma skin cancers or locally treated cervical cancer in previous 5 years. * Any medical history of symptomatic CDI within the prior 2 years. * Any clinically important abnormalities in laboratory values, vital signs, clinical chemistry, hematology, or urinalysis results. * Any positive result on Screening for serum Hepatitis B surface antigen (HBsAg) or Hepatitis C virus (HCV). * Primary or acquired immunodeficiency, including HIV infection or due to drugs, including any course of glucocorticoid therapy exceeding 2 weeks of prednisone or equivalent within 6 months prior to Screening. Human immunodeficiency virus (HIV) testing must be negative at Screening Visit. * Any clinically important abnormalities in rhythm, conduction, or morphology of the resting 12-lead electrocardiogram, at Screening. * Known or suspected history of alcohol or drug abuse within the past 2 years that might affect assessments of safety or ability of participant to comply with all study requirements. * Positive screen for drugs of abuse, or alcohol at Screening or Day -1. * History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity to drugs with a similar chemical structure or class to the study drug. * History of previous hypersensitivity, infusion-related reaction, or severe adverse reaction following administration of monoclonal antibodies (mAbs). * Previous receipt of a mAb within 6 months, or 5 antibody half-lives (whichever is longer), prior to the start of the study. * Plasma donation within one month of the Screening Visit or any blood donation/blood loss \> 500 mL during the 3 months prior to the Screening Visit. * Receipt of immunoglobulin or blood products, or expected receipt, within 6 months prior to Screening or expected to receive during the study. * Clinically significant bleeding disorder (e.g., factor VIII deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venipuncture. * Vulnerable participants, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order.