Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
The use of programmed frozen embryo transfer cycle (FET) in IVF women is associated with an increased risk of obstetric complications (pregnancy-induced hypertension, preeclampsia, postpartum hemorrhage and placenta accreta) compared to FET in natural cycle. The lack of corpus luteum in programmed cycles and the subsequent absence of circulating vasoactive substances may lead to an impaired cardio-vascular adaption to pregnancy and thereby an increased risk of pregnancy-induced hypertension and preeclampsia. The cardiovascular and metabolic adaption to pregnancy is evaluated throughout pregnancy by use of Magnetic Resonance Imaging (MRI) as well as non-invasive measurements by use of elastography and seismocardiography. Patients are screened for preeclampsia throughout pregnancy with measurements of blood pressure, urine samples as well as blood samples.
Study Type
OBSERVATIONAL
Enrollment
75
MRI performed three times during pregnancy and 6 months postpartum
Aalborg University Hospital
Aalborg, Denmark
Maternal cardiovascular adaption to pregnancy
Time frame: From early pregnancy to six months postpartum
Maternal metabolic adaption to pregnancy
Time frame: From early pregnancy to six months postpartum
Placental function and fetal oxygenation estimated by longitudinal T2* weighted placental and fetal MRI
Time frame: From early pregnancy to six months postpartum
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.