COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters. Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.
Three types single leg exercise intervantion will applied to COPD patients that devided three groups. One leg continuous exercise training will be aplied to one group. One leg HIIT exercise training will be aplied to other group. One leg resistance exercise training will be aplied to the last group. Exercise capacity and muscle strength are assesed. Lung function is measured. Electormyography is recorded. Lactate and quality of life are measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
66
single leg exercise intervantions 1. high intensity interval training 2. continous exercise training 3. resistance exercise training
Elif Kocaaga
Ankara, Turkey (Türkiye)
RECRUITINGsix minute walk test
six minute walk test in meter
Time frame: pre-intervention
cardiopulmonary exercise test
VO2 as ml/kg/min will be recorded from incremental cycle cpet test
Time frame: beginning day 2
one leg cardiopulmonary exercise test
VO2 as ml/kg/min will be recorded from incremental cycle cpet test
Time frame: beginning, day 3
quadriceps muscle strength assesing (repeated measeure)
quadriceps muscle 10 repeated max muscle strength will be recorded at kilogram,
Time frame: beginning day 1 and last day
isometrics quadriceps muscle strength assesing
quadriceps muscle isometric muscle strength will be recorded at kilogram
Time frame: beginning day 1 and last day
lung function
FEV1/FVC ratio in %
Time frame: beginning day 1 and last day
quality of life assesing
total score in 0-100 range
Time frame: beginning day 1 and last day
arterial stiffness
total vascular resitance, augmentation index @ 75 and pulse wave velocity wil be determined arterial stiffness
Time frame: beginning day 2 and last day
lactate measurement
lactate in mmol
Time frame: beginning day 2 and last day
electromyography measurement
precentage of maximum volunteer contraction) %MVC values will be presented muscle fatigue (median frequence) and activation will be shown electromyograpy (EMG)
Time frame: beginning day 2 and last day
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