Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia

Women's Hospital School Of Medicine Zhejiang University356 enrolled

Overview

Women requiring epidural labor analgesia were randomized into two groups, one with the local anesthetic chloroprocaine and the other with ropivacaine. The primary outcome was to observe the analgesic scores of the two groups of drugs as well as adverse reactions.

Mothers who met the study criteria vertebrae were included and then divided into two groups. Labor analgesia was provided by epidural anesthesia with a low concentration of local anesthetic (chloroprocaine or ropivacaine) combined with sufentanil. Data related to labor analgesia such as pain scores, motor tissue scores, and body temperature were collected and statistically analyzed to compare the efficacy and adverse effects of the two local anesthetics and to draw conclusions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

356

Conditions

Obstetric Labor

Interventions

ChloroprocaineDRUG

Selection of low concentration of chloroprocaine as local anesthetic for labor analgesia

Eligibility

Sex: FEMALEMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primigravid women with full-term pregnancies scheduled for labor analgesia * Determination of labor onset to cervical dilatation ≤ 5cm; * Visual analogue scale (VAS) pain score during contractions \>50 mm (0 mm = no pain at all, 100 mm = most intense pain); * Age ≥20 years; * American Society of Anesthesiologists (ASA) classification II * Body mass index (BMI) between 18.5 and 30 kg/m2 * Height \>155 cm * Signed informed consent. Exclusion Criteria: * Twin or multiple pregnancies * Hypertension * Severe cardiopulmonary and hepatic or renal disease * Severe pregnancy comorbidities such as preeclampsia, eclampsia, HELLP syndrome, placenta praevia, placental abruption, etc. * Cephalopelvic disproportion * History of allergy to local anesthesia * Spinal deformity * Contraindications to intrathecal anesthesia * Refusal to participate in the stud

Outcomes

Primary Outcomes

Percentage of effective analgesia

Percentage of effective analgesia within 30 min after the first epidural addition at the beginning of labor analgesia in both groups

Time frame: 30 min after the first epidural addition at the beginning of labor analgesia

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.