Effects of Obesity on COPD

Rijnstate Hospital166 enrolled

Overview

The purpose of this study is to investigate whether obese COPD patients experience more or less discomfort in daily life. Furthermore the investigators will evaluate if body composition or body fat distribution has effects on symptoms and performance.

Chronic Obstructive Pulmonary Disease (COPD) and Obesity are two major health problems. The prevalence of both is growing and there is a complex interaction between COPD and obesity. On the one hand obesity impairs lung function, with decreasing static lung volumes being the most significant effect. On the other hand there seems a beneficial role of obesity on lung function in COPD patients. This is because obese COPD patients tend to have less hyperinflation than non-obese COPD patients . An interesting question is what the net effect of these changes in lung function is on respiratory symptoms and quality of life. In this observational study, the investigators will compare obese and non-obese COPD patients. Pulmonary function, dyspnea and quality of life will be compared between the two groups.

Study Type

OBSERVATIONAL

Enrollment

166

Conditions

COPD Obesity Chronic Obstructive Pulmonary Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with COPD by a Pulmonologist defined as an obstructive lung function test with FEV1/FVC \< 0.7 and FEV1 \< 80% predicted * No exacerbation of COPD at time of inclusion * Age \> 18 years * Able to perform lung function tests and fill in the questionnaires. Exclusion Criteria: * Not able to perform lung function tests or fill in the questionnaires * Diagnosis of Asthma * Diagnosis of neuromuscular disease * Diagnosis of heart failure * Treatment for lung Malignancy in the past * Active Malignancy

Locations (1)

Department Of Pulmonology, Rijnstate Hospital, The Netherlands

Arnhem, Netherlands

Outcomes

Primary Outcomes

Dyspnoea - mMRC

Level of dyspnoea perceived in daily life measured using the Modified Medical Research Council (mMRC) dyspnoea scale. The mMRC dyspnoea scale ranges from grade 0 to 4. Higher scores mean a worse outcome.

Time frame: At inclusion

Dyspnoea - NCSI

Level of dyspnoea perceived in daily life measured using the Nijmegen Clinical Screening Instrument (NCSI). The NCSI ranges from grade 0 to 11. Higher scores mean a worse outcome.

Time frame: At inclusion

Change in dyspnoea

Level of dyspnoea using the Borg score. The Borg score ranges from grade 0 to 10. Higher scores mean a worse outcome.

Time frame: Before and after the 6 minute walking test

Secondary Outcomes

6 minute walking test

distance walked in 6 minutes measured in metres

Time frame: At inclusion

Data from ClinicalTrials.gov

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