Venoconstrictive Thigh Cuffs (VTC) are being evaluated to determine the effectiveness at reversing the headward fluid shift that occurs during weightlessness. If successful, future studies may be done to implement these as a CM to SANS. To support this effort, participants will participate in 2 preflight study sessions consisting of a VTC fit check and a baseline data collection without and with the VTC donned. Participants will also participate in 3 inflight study sessions: a VTC fit check on flight day 30 (FD30) and two separate data collection sessions on flight day 45 (FD45) and 45 days before landing (R-45). During the two in-flight data collection days, participants will be studied before and for up to 6 hours after donning the VTC.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
10
The VTC is an adjustable fabric cuff that is worn on the upper thighs to retain some fluid in the legs. It consists of wide straps and a buckle which allow it to be tightened, then velcro to secure the strap in the tightened position. There is also lacing that can be tightened for micro adjustments. Imbedded within the fabric strap is a bladder that is not used for increasing tightness but allows the pressure of the cuff to be measured and tracked.
Johnson Space Center, National Aeronautics and Space Administration
Houston, Texas, United States
Internal Jugular Vein (IJV) area
Measured using Ultrasound.
Time frame: Thigh Cuff Measures 90 days before mission, after 45 days in mission, and 45 days before return
IJV pressure
Measured using the VeinPres device during Ultrasound.
Time frame: Thigh Cuff Measures 90 days before mission, after 45 days in mission, and 45 days before return
Intraocular Pressure (IOP)
Measured using the Pneumatonometer.
Time frame: Thigh Cuff Measures 90 days before mission, after 45 days in mission, and 45 days before return
stroke volume
Measured from data collected during Ultrasound.
Time frame: Thigh Cuff Measures 90 days before mission, after 45 days in mission, and 45 days before return
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.