Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?

Ganin Fertility Center100 enrolled

Overview

There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Male Infertility

Interventions

Testicular sperm extraction (TESE)PROCEDURE

Surgical procedure used to retrieve sperm directly from the testicles of men who have low sperm production or no sperm in their ejaculate

EjaculateOTHER

Ejaculate processing for ICSI

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Cases planned to have ICSI PGT-A cycles * Males diagnosed as severe male factor infertility * Normo responder female partners Exclusion Criteria: * Leukocytospermia * Presence of varicocele. * Known genetic abnormality * Use of sperm or oocyte donors * Use of gestational carrier * Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection * Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation

Locations (1)

Ganin Fertility Center

Cairo, Maadi, Egypt

Outcomes

Primary Outcomes

Euploidy rate

Defined as the proportion of euploid blastocysts

Time frame: 15 days post ICSI

Aneuploidy rate

Defined as the proportion of aneuploid blastocysts

Time frame: 15 days post ICSI

Low mosaic rate

Defined as the proportion of low mosaic blastocysts

Time frame: Time Frame: 15 days post ICSI

High mosaic rate

Defined as the proportion of high mosaic blastocysts

Time frame: Time Frame: 15 days post ICSI

Implantation rate

defined as the percentage of successfully implanted embryos

Time frame: 6-9 weeks post-embryo transfer

Ongoing pregnancy rate

defined as a positive heartbeat on ultrasound beyond 12 weeks of gestation

Time frame: 12 weeks of gestation

Miscarriage rate

defined as pregnancy loss following confirmation of clinical pregnancy

Time frame: after 6 weeks of gestation

Clinical pregnancy rate

defined as the presence of a fetal heartbeat or gestational sac 6-9 weeks post-embryo transfer

Time frame: 6-9 weeks post-embryo transfer

Secondary Outcomes

Fertilization rate

Data from ClinicalTrials.gov

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