The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
240
Specified dose on specified days
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States
RECRUITINGNumber of participants with adverse events (AEs)
Time frame: Up to 108 weeks
Number of participants with serious adverse events (SAEs)
Time frame: Up to 108 weeks
Number of participants with AEs meeting protocol defined dose-limiting toxicity (DLT) criteria
Time frame: Up to 108 weeks
Number of participants with AEs leading to discontinuation
Time frame: Up to 108 weeks
Number of participants with AEs leading to death
Time frame: Up to 108 weeks
Maximum observed concentration (Cmax)
Time frame: Up to 104 weeks
Area under the concentration-time curve (AUC)
Time frame: Up to 104 weeks
Time of maximum observed concentration (Tmax)
Time frame: Up to 104 weeks
Objective response rate (ORR)
Time frame: Up to 104 weeks
Disease control rate (DCR)
Time frame: Up to 104 weeks
Duration of response (DOR)
Time frame: Up to 104 weeks
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
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CONTACT
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Valkyrie Clinical Trials
Los Angeles, California, United States
RECRUITINGJohn Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States
RECRUITINGLocal Institution - 0045
Columbus, Ohio, United States
NOT_YET_RECRUITINGLocal Institution - 0046
Dallas, Texas, United States
NOT_YET_RECRUITINGLocal Institution - 0049
Houston, Texas, United States
NOT_YET_RECRUITINGBC Cancer Vancouver
Vancouver, British Columbia, Canada
RECRUITINGPrincess Margaret Cancer Centre
Toronto, Ontario, Canada
RECRUITINGCentre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
RECRUITINGJewish General Hospital
Montreal, Quebec, Canada
RECRUITING...and 7 more locations