The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
240
Specified dose on specified days
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States
RECRUITINGValkyrie Clinical Trials
Number of participants with adverse events (AEs)
Time frame: Up to 108 weeks
Number of participants with serious adverse events (SAEs)
Time frame: Up to 108 weeks
Number of participants with AEs meeting protocol defined dose-limiting toxicity (DLT) criteria
Time frame: Up to 108 weeks
Number of participants with AEs leading to discontinuation
Time frame: Up to 108 weeks
Number of participants with AEs leading to death
Time frame: Up to 108 weeks
Maximum observed concentration (Cmax)
Time frame: Up to 104 weeks
Area under the concentration-time curve (AUC)
Time frame: Up to 104 weeks
Time of maximum observed concentration (Tmax)
Time frame: Up to 104 weeks
Objective response rate (ORR)
Time frame: Up to 104 weeks
Disease control rate (DCR)
Time frame: Up to 104 weeks
Duration of response (DOR)
Time frame: Up to 104 weeks
First line of the email MUST contain the NCT# and Site#
CONTACT
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Los Angeles, California, United States
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States
RECRUITINGLocal Institution - 0045
Columbus, Ohio, United States
NOT_YET_RECRUITINGLocal Institution - 0046
Dallas, Texas, United States
NOT_YET_RECRUITINGBC Cancer Vancouver
Vancouver, British Columbia, Canada
RECRUITINGPrincess Margaret Cancer Centre
Toronto, Ontario, Canada
RECRUITINGCentre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
RECRUITINGJewish General Hospital
Montreal, Quebec, Canada
RECRUITINGLocal Institution - 0031
Villejuif, Val-de-Marne, France
NOT_YET_RECRUITING...and 6 more locations