The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
84
1g acetaminophen is administered during skin closure (end of operation).
A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered during skin closure (end of operation)
1g acetaminophen is administered 6 hours after the first administration.
Seoul National University Hospital
Seoul, South Korea
RECRUITINGObstetric QoR-11K score 24 hours after end of surgery
Minimum 0, poor recovery; maximum 110, good recovery
Time frame: 24 hours after end of surgery
Numeric rating scale pain score (0-10) 4 hours after end of surgery
0, no pain; 10, worst pain imaginable
Time frame: 4 hours after end of surgery
Numeric rating scale pain score (0-10) 8 hours after end of surgery
0, no pain; 10, worst pain imaginable
Time frame: 8 hours after end of surgery
Numeric rating scale pain score (0-10) 12 hours after end of surgery
0, no pain; 10, worst pain imaginable
Time frame: 12 hours after end of surgery
Numeric rating scale pain score (0-10) 24 h after end of surgery
Time frame: 24 h after end of surgery
Numeric rating scale pain score (0-10) 48 hours after end of surgery
0, no pain; 10, worst pain imaginable
Time frame: 48 hours after end of surgery
Use of patient-controlled analgesia (FTN, micrograms) during the first 24 hours after end of surgery
Time frame: 24 h after end of surgery
Use of patient-controlled analgesia (FTN, micrograms) during the first 48 hours after end of surgery
Time frame: 48 h after end of surgery
Use of rescue analgesia during the first 24 hours after end of surgery
Junghwa Seo, MD, PhD
CONTACT
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A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered 6 hours after the first administration.
Time frame: 24 h after end of surgery
Use of rescue analgesia during the first 48 hours after end of surgery
Time frame: 48 h after end of surgery
Wound-related complications during hospital stay, up to 5 days
Time frame: From end of surgery to patient discharge, up to 5 days
Operation time
Time frame: Duration of operation
Anesthesia time
Time frame: Duration of anesthesia
Injection level of intrathecal drug
Time frame: After arrival at the operating room
Dosage of intrathecal drug (mg, bupivacaine)
Time frame: After arrival at the operating room
Sensory blockade level by time point
Time frame: 0, 5, 10 minutes after intrathecal injection and at the end of operation