Study of the ETX-4143 2.0 Device in Subjects With Eye Pain

Inclusion Criteria: * Documented history of eye pain with no relief from currently available medications or treatments * Willing to forgo participation in any other clinical stud for the duration of this study * Demonstrate sufficient cognitive awareness to comply with the examination process * Willing and able to comply with the schedule for follow-up visits * Willing to participate in the study as evidenced by signing an informed consent document Exclusion Criteria: * Women who are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study time period, including the follow-up period * Any active ocular infection or active ocular inflammation at the time of the screening visit * History of herpes keratitis, non-healing corneal epithelial defects, or neurotrophic keratopathy due to corneal herpetic disease, stem cell deficiency, diabetic keratopathy, severe lagophthalmos, or topical anesthetic abuse * Any history of significant eye surgery with the prior 90 days * Planned eye surgery during the entire study * Participation in any clinical study of an investigational product within 30 days prior to enrollment * Any history of serious, poorly controlled systemic or ophthalmic condition that could compromise the subject's ability to comply with the protocol or compromise their safety