Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
Study Type
OBSERVATIONAL
Enrollment
450
AT: Mother-infant cohort with antibiotic treatment group CS: Mother-infant cohort (Prophylactic antibiotics therapy) ND: Mother-infant cohort (Natural delivery)
The Peking University People's Hospital
Beijing, China
RECRUITINGInfant gut microbiome
* Diversity of gut microbiota * Abundance of antibiotic resistance genes in gut microbiota * Metabolic pathway of gut microbiota
Time frame: Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months)
Antibiotic treatment
* Frequency of antibiotic treatment * Kind and Dose of antibiotic; * Duration of antibiotic use;
Time frame: Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.