Stem Cell Derived Exome for Treatment of Diabetic Foot

Inclusion Criteria: 1. Clinical diagnosis of diabetic foot. 2. Signed informed consent before recruiting. 3. Age above 18 years or less than 90 years. 4. ECOG score \< 4 5. Tolerable coagulation function or reversible coagulation disorders 6. Laboratory examination test within 7 days prior to procedure: WBC≥3.0×10E9/L; Hb≥90g/L； PLT ≥50×10E9/L；INR \< 2.3 or PT \< 6 seconds above control；Cr ≤ 145.5 umul/L；Albumin \> 28 g/L；Total bilirubin \< 51 μmol/L 7. Willing and able to comply with scheduled visits, treatment plan and laboratory tests. Exclusion Criteria: 1. Patients participated in clinical trials of equipment or drugs (signed informed consent) within 4 weeks; 2. Patients accompany by ascites, hepatic encephalopathy and esophageal and gastric varices bleeding; 3. Any serious accompanying disease, which is expected to have an unknown, impact on the prognosis, include heart disease, inadequately controlled diabetes and psychiatric disorders; 4. Patients have poor compliance. 5. Allergic to the skin drug; 6. Any agents which could affect the absorption or pharmacokinetics of the study drugs 7. Other conditions that investigator decides not suitable for the trial.