Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, the investigators conducted an RCT in which the investigators exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
22
Instead of normal cycling, patients will exercise on the eccentric bike.
Normal rehabilitation will be conducted
Rehabilitation clinic Barmelweid
Erlinsbach, Switzerland
RECRUITINGUniversity Hospital Zurich, Pneumology
Zurich, Switzerland
RECRUITINGpeak exercise capacity
Time frame: 3 weeks
Peak oxygen uptake
Assesses during exercise until exhaustion using an incremental exercise protocol
Time frame: 3 weeks
ventilatory equivalent for CO2
Time frame: 3 weeks
Finger pulseoximetry
Arterial oxygen saturation will be assessed by finger clip Infrared spectroscopy
Time frame: 3 weeks
6 minute walk distance
Time frame: 3 weeks
systolic pulmonary artery pressure
Time frame: 3 weeks
total pulmonary resistance
Time frame: 3 weeks
ventricular - pulmonary arterial coupling
Time frame: 3 weeks
cardiac output
will be assessed by echocardiography using the pulse-wave doppler technique at the left ventricular outflow tract durig systole.
Time frame: 3 weeks
Arterial partial pressure for oxygen
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Time frame: 3 weeks
Arterial partial pressure for carbon dioxide
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Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Time frame: 3 weeks
Arterial oxygen saturation
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Time frame: 3 weeks
Arterial lactate concentration
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Time frame: 3 weeks
Borg CR 10 for perceived dyspnea
Time frame: 3 weeks
Borg CR 10 for perceived leg fatigue
Time frame: 3 weeks
Visual analogue scale generell well being
Time frame: 3 weeks
Visual analogue scale dyspnea
Time frame: 3 weeks