A Study to Evaluate Safety, Tolerability and Pharmacokinetics of RSN0402 in Healthy Volunteers

Inclusion Criteria: 1. Participant is overtly healthy or has no clinically significant condition as determined by PI/Sub-Investigator including medical history, vital signs, ECG, laboratory tests, and physical examination at Screening and admission (Day -2 and Day -1). 2. Participant has normal lung function assessment with FEV1 of at least 80% of the predicted value and FEV1/FVC ratio of \> 0.7 measured at Screening. 3. Availability to participate voluntarily for the entire study duration and willing to adhere to all protocol requirements. 4. Participant must be 18 to 60 years of age inclusive, at the time of signing the informed consent. 5. Male participant with body weight of ≥ 50.0 kg, female participant with body weight ≥ 45.0 kg; males or females with body mass index (BMI) of ≥ 18 to \< 30.0 kg/m² at screening. 6. Female participants of childbearing potential must have a negative serum pregnancy test result at Screening and a negative pregnancy test result at Baseline and agree to use acceptable methods of contraception as per protocol. 7. Male participants agree to use acceptable methods of contraception if the male participant's partner could become pregnant from the time of signing the informed consent until 3 months after EOS/ET. Exclusion Criteria: 1. Vulnerable participants (ie, people under any administrative or legal supervision). 2. Clinical laboratory evidence or clinical diagnosis of human immunodeficiency virus (HIV) infection, hepatitis C virus (HCV) infection, or chronic hepatitis B virus (HBV) infection (as shown by hepatitis B surface antigen \[HbsAg\] positivity). 3. Evidence of a clinically significant cardiovascular, renal, hepatic, hematological, gastrointestinal (GI), pulmonary, metabolic-endocrine, neurological, or psychiatric disease or psychiatric disease within the previous 2 years; or evidence of active airway infection. 4. Known hypersensitivity to the active substance(s) of the drug or its excipient (lactose monohydrate, which contains small amounts of milk protein) and/or intolerance with lactose. 5. History of vasovagal syncope in past 5 years. 6. History of anaphylactic/anaphylactoid reactions. 7. History of seizures including febrile seizures. 8. History of bleeding disorders or currently being treated with anticoagulants or regular using aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). 9. History of thrombotic event (including stroke and transient ischemic attack) within 6 months prior to Screening. 10. History of pulmonary arterial hypertension. 11. Cardiovascular diseases, any of the following: Severe hypertension (uncontrolled under treatment ≥ 160/100 mmHg at multiple occasions) within 3 months prior to Screening; history of myocardial infarction; history of unstable cardiac angina 12. Surgery of the GI tract (except appendectomy or simple hernia repair). 13. Any condition requiring regular concomitant treatment (including vitamins, recreational drugs, and dietary or herbal products) or likely to need any concomitant treatment during the study. As an exception, paracetamol and ibuprofen for occasional pain will be allowed. 14. Intake of any medication that could affect the outcome of the study. As an exception, contraceptives and hormone replacement therapy are allowed. The use of medicines that are potential CYP3A4 inducers or inhibitors will be restricted for at least 2 weeks prior to the first dose of the IP and during the study. 15. Use of any prescription drugs or the medication leading to prolong the QT/QTc interval within 14 days or 7 half-lives (whichever is longer) prior to dosing; over the-counter (OTC) medication, supplements, or vitamins within 7 days or 7 half lives (whichever is longer) prior to the first dose of the IP. 16. Administration of another investigational drug within the past 30 days prior to the first dose of IP. 17. Any clinically significant abnormal laboratory value or physical finding (including vital signs) that may interfere with the interpretation of study results or constitute a health risk for the participant if he/she takes part in the study, as judged by the PI/Sub-Investigator. More specifically, respiratory rate \< 12 or \> 22 rpm, heart rate (HR) \< 45 or \> 100 bpm, or systolic blood pressure (BP) ≥ 140 or \< 90 or diastolic BP ≥ 90 or \< 60 mmHg, or oxygen saturation \< 95% after a 5-minute rest. Repeat tests are permitted at Investigator's discretion. 18. Abnormal ECG findings (eg, QTcF \> 450 msec \[male\] or \> 470 msec \[female\]) at Screening and admission (Day -2 and Day -1). Repeat tests are permitted at Investigator's discretion 19. Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) \> 1.5 x upper limit of normal (ULN) or total Bilirubin \> 1.5 x ULN. 20. Pregnant or lactating females. 21. Women of childbearing potential (WOCBP) who are sexually active with the opposite sex not using acceptable effective methods of contraception (mechanical and/or hormonal contraception, intrauterine device, intrauterine hormonal releasing system or surgical sterilization, vasectomized partner etc.). 22. Participants with a positive result of drug abuse test or with a history of drug abuse at Screening. 23. Participants with a history of alcohol abuse within 1 month prior to Screening (average consuming 14 units or more of alcohol per week: 1 unit = 285 mL of beer, or 25 mL of spirits, or 125 mL of wine) or with a positive result of alcohol breath test at Screening. 24. Use of tobacco- or nicotine-containing products (eg, nicotine patches or vaporizing devices) within 3 months prior to Screening or a positive result of urine cotinine test at Screening. 25. Participants who consume food or beverage containing grapefruit/pomelo or alcohol/caffeine (eg, coffee, chocolate, cola, tea, etc.) within 48 hours prior to confinement and during the confinement. 26. Blood donation or loss of significant amount (≥ 200 mL) of blood within 30 days prior to the first dose of IP administration. 27. Unsuitable veins for repeated venipuncture or for cannulation. 28. Inability to learn the correct inhalation technique. 29. Predictable poor compliance. 30. Judged to be not eligible by the Investigator/Sponsor for any other reason