The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
44
During the experimental segment the sleep opportunity will be restricted to 5 hours/night. During the acclimation and recovery phases a 9-hour/night sleep opportunity will be provided.
During the normal sleep condition a 9-hour/night sleep opportunity will be provided throughout the 10-day inpatient visit.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITING24-hour Systolic Blood Pressure (BP)
Systolic Blood pressure will be measured in mmHg
Time frame: Day 2, Day 4, Day 7, and Day 9
24-hour Diastolic blood pressure (DBP)
Diastolic blood pressure will be measured in mmHg
Time frame: Day 2, Day 4, Day 7, and Day 9
Awake Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP)
Awake SBP/DBP will be measured in mmHg/mmHg
Time frame: Day 2, Day 4, Day 7, and Day 9
Asleep Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP)
Asleep SBP/DBP will be measured in mmHg/mmHg
Time frame: Day 2, Day 4, Day 7, and Day 9
Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP) Nocturnal dipping
SBP/DBP Nocturnal dipping will be measured in percent (%)
Time frame: Day 2, Day 4, Day 7, and Day 9
Catecholamines
Catecholamines will be measured from a 24-hour urine collection.
Time frame: Day 2, Day 4, Day 7, and Day 9
Baroreflex Sensitivity
Baroreflex Sensitivity will be measured from simultaneous electrocardiography (ECG) and noninvasive beat-to-beat BP recording.
Time frame: Day 3, Day 5, Day 8, and Day 10
Endothelial Function
Endothelial function will be estimated from flow-mediated vasodilation using ultrasound.
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Time frame: Day 3, Day 5, Day 8, and Day 10
Blood Pressure (BP) response to stressors
BP response to stressors will be measured in mmHg
Time frame: Day 3, Day 5, Day 8, and Day 10
Heart Rate response to stressors
Heart Rate response to stressors will be measured by ECG
Time frame: Day 3, Day 5, Day 8, and Day 10
DNA-methylation
Methylated gene markers in peripheral blood mononuclear cells will be obtained
Time frame: Day 3, Day 5, Day 8, and Day 10
Transcriptomic
Whole transcriptome in peripheral blood mononuclear cells will be obtained
Time frame: Day 3, Day 5, Day 8, and Day 10