Comparison of Oral Isotretinoin vs Ancomparison of Oral Isotretinoin vs Antibiotics on Corneal Thickness With AV

Superior University36 enrolled

Overview

Comparison of Oral Isotretinoin versus comparison of Oral Isotretinoin versus Antibiotics on Corneal Thickness in Patients with Acne Vulgaris

Acne is the most common skin disease requiring attention of health practitioners. It is a self-limiting disease of the pilosebaceous unit, which can lead to devastating and frustrating scars and pigmentary alterations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Cornea

Interventions

Oral IsotretinoinDIAGNOSTIC_TEST

20 mg/kg/day that affects sebaceous glands and is used to treat severe acne Frequency: Once daily

AntibioticsCOMBINATION_PRODUCT

250 mg on laternate day/3 months Frequency: Once or twice daily

Eligibility

Sex: ALLMin age: 20 YearsMax age: 43 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of either gender shall be enrolled for this study. * Acne vulgaris patients taking oral isotretinoin and oral antibiotics shall be included. Exclusion Criteria: * Patients with any ocular pathology shall be excluded. * Patients with any systemic pathology other than acne vulgaris shall be excluded. * Patients with history of contact lens wear, previous refractive surgery or injury shall be excluded.

Locations (1)

Shalamar Hospital Mughalpura

Lahore, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Optical Coherence Tomography (OCT)

Standardized OCT imaging protocols to ensure consistency and accuracy across all measurements.

Time frame: 12 Months

Snellen Chart

Visual acuity measured at 3-month and 6-month intervals. Units: Snellen fraction (e.g., 20/20, 20/40)

Time frame: 12 months

Data from ClinicalTrials.gov

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