Heterogeneity of Tertiary Lymphoid Structures Predicts Distinct Malignancy and Immune Microenvironment in Prostate Cancer: a Retrospective Cohort Study

Fudan University200 enrolled

Overview

The aim of this study was to reveal the predictive value of spatial heterogeneity and maturity difference of tertiary lymphoid structure in pathological sections of prostate cancer patients for clinical features and prognosis. It provides a new idea for the selection of prostate cancer immunotherapy population in the future.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Prostate Cancer

Eligibility

Sex: MALE

Medical Language ↔ Plain English

Inclusion Criteria: 1.patients diagnosed with prostate cancer who underwent radical prostatectomy or prostate puncture Exclusion Criteria: 1\. incomplete medical records, inadequate follow-up information, and confirmed non-prostatic acinar adenocarcinoma.

Locations (1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Correlation between the detection of TLS(tertiary lymphoid structure) and clinical features

Time frame: 1 month

Data from ClinicalTrials.gov

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