The colon can absorb iron.We propose an integrated approach utilizing colonic transendoscopic enteral tubing to deliver iron in different valence states, coupled with washed microbiota transplantation . This clinical trial aims to assess the feasibility, safety, and efficacy of this approach for the treatment of iron deficiency.
At least 60 subjects who meet all the inclusion criteria but do not meet any exclusion criteria will be enrolled in this study. Data of demographic characteristics, reticulocyte hemoglobin, ferritin and clinical outcomes will be collected. After treatment, they will enter the follow-up period for safety and efficacy evaluation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
The injection solution was 3 ferrous lactate (10ml:0.1g iron) mixed with 20ml saline.
The injection was 3 shots of ferrous lactate (5ml:100mg iron) mixed with 35ml saline.
The same volume and color as Iron sucrose.
Department of Microbiota Medicine & Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Reticulocyte haemoglobin values in blood
To compare the level of reticulocyte haemoglobin in the blood before and after administration of iron lactate, iron sucrose and saline.
Time frame: Baseline; Day 4
Serum ferritin levels
To compare the level of ferritin in the serum before and after administration of iron lactate, iron sucrose and saline.
Time frame: Baseline; Day 4
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