High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), 6MWT Assessed at High Altitude (3200m) vs Low Altitude (760m)

University of Zurich24 enrolled

Overview

To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live \>2500m on 6-minute walk distance (6MWD)

This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA \>30 mmHg who permanently live at HA \>2500 m will perform a 6-minute walk distance test near their living altitude in Aksay at 3200 m and on day 2 and 7 at 760 m after relocation

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

High Altitude Pulmonary Hypertension

Interventions

6-minute walk test (6MWT)OTHER

6-minute walk test (6MWT) will be performed according to clinical standards

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Permanently living \>2500 m * HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m * Written informed consent Exclusion Criteria: * Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)

Locations (1)

Aksay Medical Center

Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan

Outcomes

Primary Outcomes

6-minute walk distance (6MWD) on day 2 of relocation to 760 m

Change in 6MWD in meter between LA (760 m) vs HA (3200 m)

Time frame: day 2 at 760 m compared to 3200 m

Secondary Outcomes

6-minute walk distance (6MWD) on day 7 of relocation to 760 m

6-minute walk distance (6MWD) in meter between LA (760 m) and HA (3200 m)

Time frame: day 7 at 760 m compared to 3200 m

Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 2 of relocation to 760 m

Change in SpO2 in % between LA (760 m) vs HA (3200 m)

Time frame: day 2 at 760 m compared to 3200 m

Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 7 of relocation to 760 m

Change in SpO2 in % between LA (760 m) vs HA (3200 m)

Time frame: day 7 at 760 m compared to 3200 m

Heart rate at rest and at peak 6MWD on day 2 of relocation to 760 m

Change in hear rate in bpm between LA (760 m) vs HA (3200 m)

Time frame: after the first night at LA (760 m)

Heart rate at rest and at peak 6MWD on day 7 of relocation to 760 m

Change in hear rate in bpm between LA (760 m) vs HA (3200 m)

Time frame: day 7 at 760 m compared to 3200 m

Blood pressure at rest and at 6MWD on day 2 of relocation to 760 m

Change in blood pressure in mmHg between LA (760 m) vs HA (3200 m)

Time frame: day 2 at 760 m compared to 3200 m

Data from ClinicalTrials.gov

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