High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)

University of Zurich24 enrolled

Overview

To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live \>2500 m on pulmonary artery pressure (PAP)

This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA \>30 mmHg who permanently live at HA \>2500 m will have pulmonary arterial pressure (PAP) assessed by echocardiography near their living altitude in Aksay at 3200 m and at 760 m in Bishkek the day after the first and the seventh night after relocation.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

High Altitude Pulmonary Hypertension

Interventions

EchocardiographyOTHER

Echocardiography will be performed according to clinical standards

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Permanently living \>2500 m * HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m * Written informed consent Exclusion Criteria: * Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)

Locations (1)

Aksay Medical Center

Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan, Kyrgyzstan

Outcomes

Primary Outcomes

Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA)

Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)

Time frame: day 2 at 760 m vs. 3200 m

Secondary Outcomes

Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA)

Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)

Time frame: day 7 at 760 m vs. 3200 m

Cardiac output at 760 m (LA) vs at 3200 m (HA)

Change in cardiac output in l/min assessed by echocardiography between LA (760 m) vs HA (3200 m)

Time frame: day 2 and 7 at 760 m vs. 3200 m

Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA)

Tricuspid pressure gradient assessed by echocardiography between LA (760 m) vs HA (3200 m)

Time frame: day 2 and 7 at 760 m vs. 3200 m

Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA)

Tricupsid annular plane systolic excursion assessed by echocardiography between LA (760 m) vs HA (3200 m)

Time frame: day 2 and 7 at 760 m vs. 3200 m

pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA)

Change in pH by arterial blood gases assessed between LA (760 m) vs HA (3200 m)

Time frame: day 2 and 7 at 760 m vs. 3200 m

partial pressure of oxygen (PaO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA)

Data from ClinicalTrials.gov

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