High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), SDB Assessed at HA (3200 m) vs LA (760 m)

University of Zurich24 enrolled

Overview

To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live \>2500m on sleep disordered breathing

This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA \>30 mmHg who permanently live at HA \>2500 m will have nocturnal respiratory sleep studies near their living altitude in Aksay at 3200 m and on night 1 and 6 at 760m after relocation.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

High Altitude Pulmonary Hypertension

Interventions

SDB assessmentOTHER

SDB will be assessed by respiratory polygraphy according to clinical standards

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Permanently living \>2500 m * HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m * Written informed consent Exclusion Criteria: * Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)

Locations (1)

Aksay Medical Center

Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan

Outcomes

Primary Outcomes

Mean nocturnal SpO2 during the first night at LA vs HA

Change in mean nocturnal SpO2 (%) between LA (760 m) vs HA (3200 m)

Time frame: night 1 at 760 m compared to 3200 m.

Secondary Outcomes

Mean nocturnal SpO2 during the sixth night at LA vs HA

Change in mean nocturnal SpO2 (%) between LA (760 m) vs HA (3200 m)

Time frame: night 6 at 760 m compared to 3200 m.

Time spent with SpO2<90% at LA vs HA

Change in time spent with SpO2\<90% between LA (760 m) vs HA (3200 m)