The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participate din the study in 2017 to undergo follow-up examinations in 2024, in order to allow comparisons of current results with baseline data from 2017.
Study Type
OBSERVATIONAL
Enrollment
120
Change in pulmonary artery pressure in highlanders
Change in pulmonary artery pressure (RV/RA measured by echocardiography) from 2017 to 2024 in highlanders living above 2500 m.
Time frame: Year 2017 to 2024
Change in pulmonary artery pressure between highlanders and lowlanders
Difference in the change in pulmonary artery pressure (RV/RA measured by echocardiography) from 2017 to 2024 between highlanders and lowland controls.
Time frame: Year 2017 to 2024
Change in TRP/CO in highlanders
Change in TRP/CO slope from 2017 to 2024 in highlanders living above 2500 m.
Time frame: Year 2017 to 2024
Progression of oxygen desaturation index
Change in the oxygen desaturation index from 2017 to 2024 in highlanders.
Time frame: Year 2017 to 2024
Progression of quality of life
Change in the mental and physical component score of the SF-36 questionnaire from 2017 to 2024 in highlanders.
Time frame: Year 2017 to 2024
Progression of arterial blood gases
Change in the arterial blood gases from 2017 to 2024 in highlanders.
Time frame: Year 2017 to 2024
Progression of right heart strain
Change in the right heart strain from 2017 to 2024 in highlanders.
Time frame: Year 2017 to 2024
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.