This study aim to develop inflammatory score based on proper integration of several inflammatory markers and investigate whether it was associated with hematoma expansion and poor outcomes in patients with ICH .
Intracerebral hemorrhage(ICH) accounts for approximately a quarter of all stroke subtypes with high mortality and the survi- vors always have varying degrees of residual disability. However, few medical and surgical treatments are clearly beneficial comparing with ischemic stroke. Hematoma expansion, which is a determinant of poor outcomes, occurs in about 30% of ICH patients especially at the early stage. Attenuating hema- toma expansion is a compelling target for ICH treatment, while the outcomes have not been accordingly improved after curbing the growth of hematoma in several clinical trials. It will be more helpful if a predictor can identify the risk of hematoma expansion and poor outcome rapidly and accurately. Thus the antiexpansion treatment to the patients with positive of such predictor is likely to provide clinical benefits.
Study Type
OBSERVATIONAL
Enrollment
100
Patient needs follow up ct brain , cbc , CRP
primary (main): appropriate predictor of hematoma expansion and poor outcomes with good accuracies.
The current study suggests inflammatory score consisting of appropriate integration of NLR, PLR, MLR, SII, LDH, and CRP is independently associated with hematoma expansion and poor outcomes of different terms in ICH patients, including secondary neurological deterioration within 48 hours, 30-day mortality, and 3-month poor mRS. Moreover, inflammatory score greater than or equal to 5 is validated as an appropriate predictor of hematoma expansion and poor outcomes with good accuracies
Time frame: Baseline
Secondary outcome
Secondary (subsidiary) : 1. inflammatory score based on proper integration of several inflammatory markers 2. investigate whether it was associated with hematoma expansion in patients with ICH Helping . in better outcome and good prognosis 3. prediction of secondary neurological deterioration within 48 hours, 30-day mortality, and 3- month poor mRS Secondary (subsidiary) : 1. inflammatory score based on proper integration of several inflammatory markers 2. investigate whether it was associated with hematoma expansion in patients with ICH Helping . in better outcome and good prognosis 3. prediction of secondary neurological deterioration within 48 hours, 30-day mortality, and 3- month poor mRS
Time frame: One year
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