This is a multicenter observational study of patients undergoing focal therapy for prostate cancer in Asia
Patients undergoing Focal Cryotherapy, Focal HIFU, Focal IRE, Focal Laser ablation, or other partial gland ablation modalities for prostate cancer will be recruited.
Study Type
OBSERVATIONAL
Enrollment
500
Ablation of \<75% of the prostate gland for limited volume prostate cancer
Singapore General Hospital
Singapore, Singapore
RECRUITINGOverall Survival
Living at 20 years after treatment
Time frame: 20 years
Metastasis-Free Survival
Metastasis Free at 20 years after treatment
Time frame: 20 years
Progression-Free Survival
Progression-Free (Local or Systemic) at 20 years after treatment
Time frame: 20 years
Short-term Clinically Significant Prostate Cancer Recurrence
12-18 month infield and outfield recurrence rate
Time frame: 18 months
Intermediate-term Clinically Significant Prostate Cancer Recurrence
5 year infield and outfield recurrence rate
Time frame: 5 years
Sexual Function
Change in Expanded Prostate Index Composite (EPIC) Sexual Summary Score (0-100, with 100 being the maximum) post-Focal Therapy (FT) compared to baseline at 1,3, 6, 12 months
Time frame: 12 months
Urinary Function
Change in Expanded Prostate Index Composite (EPIC) Urinary Summary Score (0-100, with 100 being the maximum) post-FT compared to baseline at 1,3, 6, 12 months
Time frame: 12 months
Bowel Function
Change in Expanded Prostate Index Composite (EPIC) Bowel Summary Score (0-100, with 100 being the maximum) post-FT compared to baseline at 1,3, 6, 12 months
Time frame: 12 months
Radical Intervention-free Survival
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Free of Radical Prostatectomy or Radiation at 5 years
Time frame: 5 years
Treatment Failure-free Survival
Free of Radical Prostatectomy, Radiation, Whole-gland Ablation, Hormonal Therapy to Transition to Watchful Waiting at 5 years
Time frame: 5 years
Intervention-Free Survival
Intervention (Focal or Whole Gland/ Radical)-free at 20 years
Time frame: 20 years
Radical Intervention-Free Survival
Radical Intervention (Radical Prostatectomy or Radiation)-Free at 20 years
Time frame: 20 years
Failure-Free Survival
Failure (Whole Gland/ Radical intervention, use of Hormonal Therapy or transition to Watchful Waiting)-free at 10 years
Time frame: 10 years
Failure-Free Survival
Failure (Whole Gland/ Radical intervention, use of Hormonal Therapy or transition to Watchful Waiting)-free at 20 years
Time frame: 20 years