Retrospective Study of Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients

University Hospital, Strasbourg, France100 enrolled

Overview

Invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients. There is little recent data in heart transplantation, particularly on the incidence and risk factors of fungal infections. . It is therefore important to have recent data on incidence, risk and prognostic factors in order to improve the management of this severe complication.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Invasive Fungal Infections

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient ≥18 years old * Heart transplant * Invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022 * Proven or probable infection with filamentous fungi according to EORTC/MSGERC criteria (20): * Invasive aspergillosis * Mucormycosis * Fusarium wilt * Scedosporiosis * Other filamentous fungus infection * Subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research. Exclusion Criteria: * Patient having expressed his opposition to participating in the study * Patient not having a liver transplant * Subject under guardianship, curatorship or safeguard of justice.

Locations (1)

Outcomes

Primary Outcomes

To identify the incidence, risk factors and prognostic factors associated with invasive fungal infections caused by filamentous fungi in heart transplant patients.

1. Incidence: number of cases of invasive fungal infection compared to the number of heart transplant patients per year in the study centers 2. Risk factors: Case-control study. Clinical, microbiological or radiological factors statistically associated with cases of invasive fungal infection compared to controls. 3. Prognostic factors: Clinical, microbiological or radiological factors of invasive fungal infections associated with mortality at the 12th week.

Time frame: Up to 2 years