Randomized clinical trial evaluating the effect of acetazolamide on sleep disordered breathing in women compared to men travelling to 3600 m.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
270
Administration of 1x125mg acetazolamide in the morning, 1x125mg in the evening, starting 24 hours before departure to 3600 m.
Administration of equally looking placebo capsules in the morning and in the evening, starting 24 hours before departure to 3600 m.
National Center for Cardiology and Internal Medicine
Bishkek, Gorod Bishkek, Kyrgyzstan
RECRUITINGNocturnal oxygen desaturation index (ODI)
Sex-related difference in the altitude-induced change in the ODI (number of ∆SpO2 \>3% per hour time in bed measured by pulse oximetry) between acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 1 at 3600 m
Nocturnal oxygen saturation (SpO2)
Sex-related difference in the altitude-induced change in the mean nocturnal oxygen saturation measured by pulse oximetry between acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 1 at 3600 m
Nocturnal oxygen saturation (SpO2)
Sex-related difference in the altitude-induced change in the mean nocturnal oxygen saturation measured by pulse oximetry between acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 2 at 3600 m
Apnea/hypopnea index (AHI)
Sex-related difference in the altitude-induced change in the mean number of apneas/hypopneas per hour between the acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 1 at 3600 m
Apnea/hypopnea index (AHI)
Sex-related difference in the altitude-induced change in the mean number of apneas/hypopneas per hour between the acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 2 at 3600 m
Subjective sleep quality
Sex-related difference in the altitude-induced change in subjective sleep quality assessed by a 100-mm visual analog scale between the acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 1 at 3600 m
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Subjective sleep quality
Sex-related difference in the altitude-induced change in subjective sleep quality assessed by a 100-mm visual analog scale between the acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 2 at 3600 m
Nocturnal oxygen desaturation index (ODI)
Sex-related difference in the altitude-induced change in the ODI (number of ∆SpO2 \>3% per hour time in bed measured by pulse oximetry) between acetazolamide and placebo group.
Time frame: Night 1 at 760 m and Night 2 at 3600 m