Prevention of Post-traumatic Stress Disorder after traumatic Brain surgeries by using either subanesthetic ketamine or dexmedetomidine infusion.
after being informed about the study and potential risks. All patients giving written consent will be randomized by double blind manner into two equal groups (K group and D group). Using computer generated randomization table; each group consists of 26 patients: K group (n=26): Patient will receive with 0.5 mg/kg/h ketamine infusion. D group (n=26): Patient will receive 0.1 ug/kg/h dexmedetomidine infusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
52
0.5 mg/kg/h ketamine infusion
0.1 ug/kg/h dexmedetomidine infusion
Faculty of Medicine,Zagazig University
Zagazig, Sharqia Province, Egypt
(PTSD)
To measure the change in PTSD symptom severity using the PTSD Checklist
Time frame: 6 months
VAS
postoperative pain
Time frame: (24 hours, 48 hours, and 1 month)
postoperative delirium
using the confusion assessment method criteria
Time frame: twice daily for 3 days
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